I'm 27 and I've got 4 now (8, 4, 3, 18 mo) and one on the way. All birthed without drugs. All 4 are boys, we don't know on the 5th yet, but if she's a girl she'll be just a weeeeee bit spoiled. ;)
That is just crazy that is.... I wish you and your wife all the blessings that they will provide.